诱导多能干细胞研究进展

Progress in Induced Pluripotent Stem Cells

成熟的体细胞过表达转录激活因子Oct4、Sox2、Klf4和c-Myc能够转化为具有多能性的干细胞,称为诱导多能干细胞。类似于胚胎干细胞,诱导多能性干细胞具有自我更新和多向分化潜能性两个主要特征。同胚胎干细胞相比,诱导多能干细胞不仅能够为以细胞替代治疗为核心的再生医学提供无限的细胞来源,而且有望解决胚胎干细胞临床开发面临的伦理道德及免疫排斥问题。从诱导多能干细胞技术的建立、重编程的机理及其在临床中的应用几方面作简要综述。

Enforced ectopic expression of transcription factors Oct4, Sox2, Klf4 and c-Myc can reprogram matured somatic cells into pluripotent state, leading to the generation of induced pluripotent stem cells （ iPSCs ） . Similar as embryonic stem cells （ ESCs ） , iPSCs have the characters of self-renewal and pluripotency. Comparing to ESCs, iPSCs can not only provide unlimited cell source for regenerative medicine, but also hold promise to override the ethical concerns and immune rejection problems correlated with clinic development of ESCs. Here we gave a brief review on the development of iPSC technology, reprogramming mechanisms and clinic development of iPSCs.