泮托拉唑致过敏性休克文献分析

Literature analysis of pantoprazole-induced anaphylactic shock

目的:探讨泮托拉唑致过敏性休克的相关因素,为临床合理用药提供参考。方法:查阅文献资料,总结泮托拉唑致过敏性休克的相关因素并探讨其临床应用的安全性。结果:有10篇关于泮托拉唑致过敏性休克的报道,80%为男性患者,大多发生在用药后的30 min内,口服、静脉均可导致。结论:泮托拉唑可致过敏性休克,其可能与性别、代谢酶基因多态性有关。使用过程中应正确选择用药人群、合理配伍,加强用药监护及用药教育,尽早发现严重不良反应的发生并及时处理。

OBJECTIVE To investigate the impact factors of pantoprazole-induced anaphylactic shock, and provide reference for clinical medication. METHODS The literature of anaphylactie shock induced by pantoprazole were collected and analyzed statistically, the related factors were summarized to explore the safety of its clinical applications. RESULTS Totally 10 cases of the pantoprazole-induced anaphylaxis were reported , 80% were male patients, most occurred within 30 minutes after admin istration, oral or intravenous administration both could cause anaphylaetic shock. CONCLUSION Pantoprazole can cause ana- phylactic shock, which may be related to gender, metabolic enzyme gene polymorphism. We should choose the right popula- tion, reasonable compatibility, provide pharmaceutical care and education, early detection of serious adverse reactions and time- ly management.