HIV整合酶结构、功能及其二酮酸类抑制剂研究进展

Research Progress of HIV Integrase and Its Diketo Acid Inhibitors

HIV整合酶是人类免疫缺陷病毒(HIV)进入宿主细胞复制过程中必不可少的3种酶之一,而人体组织中没有其生物功能类似物,故HIV整合酶是抗艾滋病药物研究的理想靶标。总结了HIV整合酶的结构、生物功能以及目前关于二酮酸类整合酶抑制剂的最新研究进展,为研究新型HIV整合酶抑制剂提供参考。

HIV integrase is one of the three essential enzymes for HIV retroviral replication and it hasnlt been found in human tissue. Therefore it is a rational target for the development of new anti-HIV drugs. Here, the recent progress of HIV integrase inhibitors is reviewed to provide some useful information for further research and development of the HIV integrase inhibitors.