鹰嘴豆芽素A7-O-β-D-吡喃木糖苷的合成与抗缺氧活性研究

Synthesis and Anti-hypoxia Activity of Biochanin A-7-O-β-D-xylopyranoside

以乙酰溴代木糖和鹰嘴豆芽素A为原料,采用相转移催化法在鹰嘴豆芽素A 7位羟基处引入糖苷,合成得到了鹰嘴豆芽素A 7-O-β-D-吡喃木糖苷,方法简单,条件温和,收率较高。产物结构通过1H NMR、IR和ESI-MS分析确认。通过小鼠常压密闭耐缺氧实验和化学物质中毒实验对其抗缺氧活性进行评价,结果表明:鹰嘴豆芽素A 7-O-β-D-吡喃木糖苷表现出了较高的抗缺氧活性。

Using α-D-xylopyranosyl bromide and biochanin A as the starting materials, biochanin A-7-O-β-D- xylopyranoside was synthesized by means of phase transfer catalysis. This route has advantages of mild reaction conditions, simple procedures and high yield. The structure was characterized by IH NMR, IR and EI-MS spectra. The anti-hypoxic activities of the title compound were examined using the normobaric hypoxia and chemistry poisoning hypoxia model of mice. The results indicate that the title compound exhibits high anti-hypoxic activity.