两种支架含铜宫内节育器铜离子释放及表面腐蚀的研究

Study on the Release of Copper Ion and Corrosion for Intrauterine Contraceptive Device with Two Kinds of Cu-containing Stent

通过两种支架含铜宫内节育器在体外模拟宫腔液中浸泡,来了解铜离子释放的过程及铜丝和支架表面形貌的腐蚀。结果表明,不锈钢支架含铜宫内节育器在浸泡第一周有爆释现象（25~12 mg/d）,后期铜离子释放变得缓慢和均衡。记忆合金支架含铜宫内节育器在两个月的释放过程中较为缓慢和均衡（0.5~5 mg/d）。在200倍光学显微镜下对两个月浸泡前后铜丝表面形貌观察表明,不锈钢支架节育器的铜丝腐蚀情况明显比记忆合金支架的铜丝腐蚀严重。

Two kinds of Cu-containing intrauterine contraceptive device （Cu-IUD） has been evaluated through the study on the release of copper ion and corrosion of copper surface in artificially formulated fluid, The result showed that the copper ions were released profusely from the stainless steel stents Cu-IUD in the first week of soak （25-12 μg/d） , and then it became slowly and steady. The release of the copper ions from the titanium nickel shape memory alloy stents Cu-IUD were always slowly and steady in two months（0.5-5 μg/d）. It obviously shows that the corrosion on copper surface of stainless steel stents Cu-IUD were more serious than titanium nickel shape memory alloy stents Cu-IUD by using 200 times microscope testing before and after soaking in formulated fluid,