Cyclin D1,Rb在胆管癌中的表达和意义

Significance and expression of Cyclin D1, Rb in bile duct carcinoma

目的 探讨CyclinD1,Rb的表达与胆管癌的临床病理参数和预后的关系。方法 采用S P法进行CyclinD1,Rb的免疫组化染色。结果 CyclinD1的阳性表达率为5 2 38% (2 2 42 ) ,CyclinD1的阳性表达与胆管癌的分化程度 (P =0 .0 44 ) ,肝侵犯 (P =0 0 46 ) ,临床分期 (P =0 0 0 1) ,生存期 (P =0 0 0 11)有关。Rb与胆管癌的分化程度 (P=0 0 0 5 2 )、临床分期 (P =0 0 0 42 )、淋巴结转移 (P =0 .0 0 6 8)有关。结论 CyclinD1,Rb都与胆管癌的一些临床病理参数有关 ,CyclinD1还是提示胆管癌预后的良好标志物。

Objective To investigate the correlation between the expression of Cyclin D1,Rb and clinicopathologic parameter in bile duct carcinoma(BDC), and evaluate the potential prognostic value. Methods The expression of Cyclin D1, Rb in BDC was detected by immunochemical staining(S P method). Results Of 42 samples, 22 cases exhibited Cyclin D1 positive expression(52.38%), correlated with histological grade(P=0.044), hepatic invasion(P=0.0046), clinic stage(P=0.0001) and survival time(P=0.0011). The Rb positive rate was 57.14%(24/42), while the expression was related to histologic grade(P=0.0052), clinic stage(P=0.0042), and lymphatic metastasis(P=0.0068). Conclusions Ccylin D1 and Rb are correlated with some clinicopathologic parameter of BDC, and Cyclin D1 is a valuable prognostic marker of BDC.