摘要
首个噁唑烷酮类抗菌药利奈唑胺自2000年上市以来,其耐药性问题日趋严重,开发新型噁唑烷酮类抗菌药物成为研究热点之一。综述了近年来对利奈唑胺C环进行的结构改造及相关衍生物的研究进展,旨在为噁唑烷酮类抗菌药的深入研发提供参考。
Since the first oxazolidinone antibiotic linezolid was marketed in 2000, the problem of its drug resistance has been growing worse. The developments of new oxazolidinone compounds have become a research hotspot. The recent developments in structural modifications on ring C of linezolid and research on the related derivatives were reviewed so as to provide references for the further research and development of oxazolidinone antibiotics.
出处
《药学进展》
CAS
2014年第4期274-278,共5页
Progress in Pharmaceutical Sciences
关键词
噁唑烷酮
利奈唑胺
C环
结构修饰
抗菌活性
oxazolidinone
linezolid
ring C
structural modification
antibacterial activity
