复方维甲酸霜的研制及其治疗黄褐斑疗效观察

Preparation and Therapeutic Effect on Chloasma of Compound Tretinoin Cream

目的 :制备复方维甲酸Ⅰ号、Ⅱ号 ,观察对黄褐斑的疗效。方法 :以维甲酸、曲酸、尿囊素为主药 ,加基质制成 ,其中维甲酸用β-环状糊精包裹。结果与结论 :复方维甲酸霜处方设计合理 ,工艺稳定 ,易于掌握 ;

OBJECTIVE:To prepare compound tretinoin cream No I,No II and observe their effects on chloasma.METHODS:The cream was prepared by taking tretinoin,kojoic acid and allantoin as main components and adding base material.The tretinoin was encapsulated with β-cyclodextrin.RESULTS & CONCLUSION:The prescription of compound tretinoin cream is rational,preparation technic being stable and therapeutic effect on chloasma is satisfactory.