0~3岁试管婴儿体格发育的meta分析

A Meta Analysis of the Physical Development of 0~ 3-year-old Test Tube Babies

目的探讨辅助生殖技术（ Assisted Reproductive Technology, ART）婴幼儿的体格发育情况,评价ART的安全性。方法计算机检索中国学术期刊网络出版总库,维普中文科技期刊全文数据库,中国博士学位论文全文数据库, PubMed, EBSCO 全文数据库,德国 SPRINGER 公司期刊数据库,和 Cochrane Library 等,并辅助其他检索方式,纳入 ART术后妊娠和自然妊娠（ Nature conceived, NC）出生的0~3岁婴幼儿体格发育状况比较的队列研究,并使用 RevMan 5.0进行 Meta分析。结果 meta分析结果显示辅助生殖技术子代体格发育与自然妊娠儿相比,差异无统计学意义（ P=0.14）。其 OR （95%CI）为OR=1.80,95%CI （0.83,3.92）。结论辅助生殖技术婴幼儿生长发育与自然妊娠儿无差异,提示ART不影响婴幼儿体格发育。

Objective To evaluate the safety of ART by assessing physical development of children born with assisted reproduc-tive technology （ ART） . Methods Cohort study of the comparison between physical development of 0~ 3-year-old children con-ceived by assisted reproductive technology and by nature conceived （ NC） was conducted in China Academic Journal Network Publish-ing Database, VIP Database for Chinese Technical Periodicals, China Doctoral Dissertations Full-text Database, PubMed, EBSCO, Springer-Link, Cochrane Library and other relevant resource websites. Assisted by RevMan 5.0, the result was processed by meta a-nalysis. Results Results of meta analysis showed that in terms of physical growth of children, there was no statistically significant difference between the assisted reproductive technology and natural pregnancy . （P=0.14） OR （ 95%CI） =1.80, 95%CI （0.83, 3.92）. Conclusion Assisted reproductive technology does not affect the physical development of infants.