周围神经系统损伤与细胞凋亡的互相影响

Mutual Influence of Peripheral Nervous System Injury And Apoptosis

细胞凋亡在中枢神经损伤中的作用越来越受到重视,神经根慢性压迫性损伤可以引起发出该神经根的脊髓节段前角运动神经元凋亡,与损伤程度正相关,可能的机制:神经根的慢性压迫性损伤最终使中枢神经细胞生存信号缺失或失营养,触发细胞程序性死亡;通过对NGF与凋亡的关系的研究将认识它的治疗作用,钙离子通道拮抗剂、蛋白质合成阻滞剂等也显示了对抗神经细胞凋亡的作用。

The effect of apoptosis in the central nervous injury is attached more and more importance to. Chronic oppressive injury in nerve root can give rise to apoptosis of anterior horn motor neurons in the spinal segment of the nerve root, which is positively corre-lated with the degree of injury. The mechanism may be that chronic oppressive injury in nerve root eventually resulted in the deletion of signal for central nervous cells or the loss of nutrition, triggering programmed cell death. Treatment for apoptosis can be found out based on the relationship between NGF and apoptosis. Calcium channel antagonists and the protein synthesis blocker are also effective for curing nerve cell apoptosis.