病毒性肝炎患者血清IV—C、HA和LN水平与肝纤维化的关系

The relation between serum IV type collagen,hyaluronic acid,lameller mucin level and liver fibrosis of virus hepatitis patients

目的 :研究血清纤维化指标透明质酸、IV型胶原和层粘蛋白与肝纤维化程度的关系 ,寻找肝纤维化敏感可靠的血清指标。方法 :用放射免疫法测定 81例各种类型肝病血清IV型胶原 (IV—C)、透明质酸 (HA)、层粘蛋白 (LN)。结果 :三项指标分别在急性肝炎、慢性肝炎轻、中、重型和肝硬化中依次升高 ,差异有显著性 (P <0 0 5)。结论 :血清HA、IV—C、LN是反应肝纤维化的敏感指标 ,极大增强临床诊断的准确性和可靠性 ,动态观察上述指标的变化既可掌握患者病情的演变 ,为防治肝纤维化药物的筛选奠定基础。

Objective:To study the relation between serum IV type collagen,hyaluronic acid,lameller mucin and the level of liver fibrosis and find out a sensitive and reliable serum index for liver fibrosis.Methods:Using radioimmunoassy to detect serum IV type colagen,hyaluronic acid and lameller mucin on 81 cases of various type hepatitis patients. Results:The three items of index in acute hepatitis,chronic hepatitis(mild,medium and severe type).cirrhosis of liver are increased in proper order respectively with significant difference(P<0.05).Conclusions:Serum IV type collagen,hyaluronic acid and lameller mucin are the sensitive index of liver fibrosis.It gives maximum increasing of accuracy and reliability on clinical diagnosis. Dynamic observation on changes of these index may grasp the development of patient's condition and lay a foundation for screening medicine for liver fibrosis.