野珍珠汁的急性毒性和致突变性试验研究

THE STUDY ON THE ACUTE TOXICITY AND MUTAGENICITY OF THE YEZHENZHU JUICE.

野珍珠汁为天然植物大乌泡 (Rubus m ultibracteatus level.et Vant.)的果实所榨取的原汁 ,富含 VB1 、VB2 、VC、铁等营养素 ,可作饮料和保健食品。根据《食品安全性毒理学评价程序》的要求 ,采用小鼠急性毒性试验、Am es试验、小鼠微核试验、小鼠精子畸变试验对其急性毒性和致突变性进行了测试。试验结果 :野珍珠汁经口急性毒性 (L D5 0 )大于2 1.5 g/ kg体重 ,属实际无毒物质 ;在 Am es试验、小鼠微核试验、小鼠精子畸变试验中均未呈现致突变性。

The yezhenzhu juice was made of the fruit of the rubus multibracteatus level.et vant.The juice is rich in nutrients,such as VB 1,VB 2,VC,iron etc.It may be useful in making beverages and health food.In this paper,it was examined by the acute toxicity test,Aems test,Micronuclei test of bone marrow cell and sperm shape abnormality test in mice,according to the toxicological assessment procedures on food safety.The results showed that the LD 50 of Yezhenzhu juice was more than 21 5g/kg body weight,and that it was not found any mutagenecities in the three mutagenic tests.