1988～1992年中国非综合征性唇腭裂发生率的动态变化

VARIATION OF INCIDENCE OF NONSYNDROMIC CLEFT LIP AND CLEFT PALATE FROM 1988 TO 1992 IN CHINA.

目的 :了解我国 1988～ 1992年非综合征性唇腭裂发生率的动态变化趋势及流行病学特征。方法 :在 1988～ 1992年期间 ,采用以医院为单位的整群抽样方法 ,对全国 5 0 0多所医院孕 2 8周至产后 7天的 4349例非综合征性唇腭裂病例进行回顾性分析。结果 :我国 5年非综合征性唇腭裂发生率无显著性差异 ,城乡发生率也无显著性差异。男性发生率为 14.9/万 ,女性发生率为 11.7/万 ,差异有显著性 ,非综合征性唇腭裂的性别比为 1.3∶ 1。三类非综合征性唇腭裂各自的发生率为 :唇裂合并腭裂 :7.8/万 ,单纯性唇裂 :3.8/万 ,单纯性腭裂 :1.8/万。结论 :我国非综合征性唇腭裂发生率无变化趋势 ,城乡无差异。男性高于女性 ,唇裂合并腭裂为最常见类型。

Objective:To study the variation of trend in the incidence and epidemiological characteristics of nonsyndromic cleft lip with or without cleft palate during the period from 1988 to 1992.Methods:From 1988 to 1992,data were collected from more than 500 hospital based units involved in a monitoring program and were analyzed by the National Center for Birth Defects Monitoring.The monitored subjects were the hospitalized births from 28 weeks gestation to a period within 7 days after delivery.Results:The variation in the incidence of nonsyndromic cleft lip with or without cleft palate was not significant,and the difference between urban and rural areas not too.The incidence is as high as 14 9/10 4 in males and 11 7/10 4 in females with significant difference.The male/female sex ratio for case was 1 3.The incidences of three types of nonsyndromic cleft lip with or without cleft palate were 7 8/10 4,3 8/10 4,1 8/10 4 respectively for cleft lip with cleft palate,cleft lip alone and cleft palate only.Conclusion:There is no variation in the trend of nonsyndromic cleft lip with or without cleft palate in China during the period from 1988 to 1992 and no significant difference between urban and rural areas.The incidence is higher in males than that in females.The most common type is the cleft lip with cleft palate.