文拉法辛与阿米替林治疗抑郁症随机对照研究

Randomized Control Study on the Effect of Venlafaxine and Amitriptyline on depression

目的 :观察文拉法辛治疗抑郁症的疗效及副作用。方法 :与阿米替林比较 ,疗程 6周 ,用HAMD、HAMA量表 ,在用药前及用药后 4 ,7,14 ,4 2d评定 ,按减分率判断疗效 ,用TESS观察不良反应。结果 :文拉法辛起效时间 ( 8.5 2± 4 .4 7)d ,较阿米替林快 ,显效率 83 % ,与阿米替林相近 ,而口干、便秘、视物模糊、心动过速、厌食等副反应出现率明显较阿米替林低 (P <0 .0 1,0 .0 5 )。结论 :文拉法辛与阿米替林比较治疗抑郁症疗效肯定 ,起效快 。

To investigate the efficacy and adverse effects of venlafaxine in the treatment of depression, patients were given venlafaxine or amitriptyline for 6 weeks. The efficacy of the drugs were assessed by using HAMD and HAMA at the 4th, 7th, 14th and 42nd day before and after the medication. The adverse effects were evaluated by TESS. Our results showed that the effect time of venlafaxine was (8.52±4.47) d, which was fasler the that of amitriptyline. The effective rate of venlafaxine was 83%, which was faster the that of amitriptyline. but venlafaxine caused less dry mouth, constipation, blurred vusion, tachycardia and anorexia etc. It is concluded that venlafaxine worked faster with less side effect in the treatment of depression as compared with amitriptyline.