肺炎衣原体肺炎的实验鼠模型

Experimental mouse model of Chlamydia pneumoniae strain pneumonitis

目的 :评价以小鼠作为肺炎衣原体感染实验动物模型的价值。 方法 :以肺炎衣原体鼻内接种 Icr小鼠 ,通过不同时点 (6 0天内 )处死动物 ,观察其肺部的病理改变。 结果 :鼻内接种肺炎衣原体后 ,Icr小鼠产生肺部感染 ,特征性病理改变是斑片状间质性肺炎 ,早期 (7天以内 )病变较重 ,以中性粒细胞浸润为主 ,并伴有泡沫细胞堆积 ;后期 (14天以后 )病变开始减轻 ,以中性粒细胞和淋巴细胞混合浸润为主 ,并逐渐转为以淋巴细胞浸润为主。 结论 :给 Icr小鼠鼻内接种肺炎衣原体可引发肺部感染 ,该模型有助于对肺炎衣原体感染发病机制的研究。

Objectives: To evaluate mice as experimental animal for Chlamydia pneumoniae, a common cause of acute respiratory infections in human. Methods: Intranasal inoculation of Icr mice with C. Pneumoniae induced a prolonged course of lung infection, as demonstrated by persistence of lung pathology(60 days). Results: Icr mice were susceptible to C. pneumoniae. Lung pathology was characterized by patchy interstitial pneumonitis with predominately neutrophil leukocyte infiltration in the early(7 days) and lymphocytes infiltration in the later stages(14 days later) of infection. Conclusions:Icr mice were susceptible to C. pneumoniae and the mouse model is useful for the investigation of the pathogenesis of C. pneumoniae infection.