心脑血管疾病患者胆固醇酯转运蛋白活性测定

Determination of cholesteryl ester transfer protein activity in patients with cardiocerebrovascular diseases

目的 :探讨胆固醇酯转运蛋白 (CETP)活性与心脑血管疾病的关系。 方法 :应用体外合成 1 4 C标记的高密度脂蛋白 (HDL )样颗粒 ,测定了 45例冠心病患者、2 6例脑卒中患者和 40例健康人 CETP活性。 结果 :冠心病患者、脑卒中患者 CETP活性分别为 (17.6± 5 .4) %、(15 .2± 3.8) % ,而健康人为 (12 .7± 2 .0 ) % ,两组患者与健康人比较均有显著差异 (P<0 .0 1)。 结论 :提示 CETP与动脉粥样硬化的发生、发展密切相关。

Objectives:To evaluate the relationship between the activity of cholesteryl ester transfer protein(CETP) and cardiocerebrovascular diseases. Methods:The CETP activity of 45 cases of coronary heart disease(CHD) and 26 cases of stroke were measured using the synthetic substrate of 14 C radiolabeled discoidal bilayer particles as the cholesteryl ester donor and LDL as receptor. Results:The CEPT activity( x±s) of CHD and stroke patients were(17.6±5.4)% and(15.2± 3.8 )%,while the healthy controls were(12.7±2.0)%.The CEPT activities in CHD and stroke patients were significantly higher than that in healthy controls( P <0.01). Conclusions: CETP is related to the occurrence and development of atherosclerosis.