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经导管冠状动脉内酒精注射量及注射速度与心肌梗死面积关系研究

Study of relationship between the volume, injection velocity of intracoronary alcohol and myocardial infarct size
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摘要 目的探讨经导管冠状动脉内无水酒精注射量及注射速度与心肌梗死面积的关系。方法用20只小型猪,全部接受经导管心肌化学消融术,根据冠状动脉内无水酒精注射量、注射速度随机分为4组,每组5只。定量计算术后6小时相应心肌梗死面积,分别比较消融时无水酒精注射速度相同,但注入酒精量不同及消融时酒精注入量相同,但注射速度不同二组间心肌梗死面积。结果(1)以预设恒定酒精注射速度(0.2 ml/s),注入酒精量 2.0ml组相应心肌梗死面积(n= 5):(4.3±2.7)%,注入酒精量 0.5ml组相应心肌梗死面积( n= 5)( 10.1±4.6)%,两组比较心肌梗死面积不同(0.02< P< 0.05)。(2)以恒定酒精量注入,注射速度分别设为1.2 ml/s及 0.06ml/s两组心肌梗死面积分别为(7.1±1.6)%及(5.8±1.2)%,比较两组心肌梗死面积,无统计学差异(0.05<P<0.2)。结论经导管心肌化学消融术中,心肌梗死面积大小与冠状动脉内无水酒精注入量有关,与冠状动脉内无水酒精注射速度无关。 Objective To investigate the relationship between the volume, injection velocity and myocardial infarct size during myocardial ablation by catheter. Methods Twenty miniature pigs were all performed myocardial ablation by catheter and were at random equally divided into four groups (n = 5 in each) according to the volume and the injection velocity of intracoronary absolute alcohol. The myocardial infarct size was measured 6 hours after myocardial ablation and compared the myocardial infarct area between different groups with different volume of intracoronary absolute alcohol and compared the myocardial infarct size between different groups with different injection velocity. Results The myocardial infarct size in groups with different volume of intracoronary absolute alcohol (0.5ml and 2.0ml) are (4.3 ± 2.7)% and (10.1 ± 4.6)% respectively; The myocardial infarct size in groups with different injection velocity of intracoronary absolute alcohol (l.2 ml/s and 0.06ml/s) are (7.1 ± 1.6)% and (5.8± 1.2)% respectively; There were significant differences in myocardial infarct size with different volume of intracoronary absolute alcohol during myocardial ablation by catheter (0.02< P < 0.05) but no apparent differences were found in myocardial infarct size with different injection velocity of intracoronary absolute alcohol (0.05< P< 0.2). Conclusion The myocardial infarct size is in relation to the volume of intracoronary absolute alcohol during myocardial ablation by catheter, but have no relation to the injection velocity of intracoronary absolute alcohol.
出处 《中国介入心脏病学杂志》 2001年第1期44-45,共2页 Chinese Journal of Interventional Cardiology
基金 辽宁省科学技术基金资助
关键词 心肌梗塞 消融 无水酒精 治疗 Myocardial infarction Ablation Absolute alcohol
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  • 1罗向东,中华创伤杂志,1994年,10卷,185页
  • 2杨映波,第三军医大学学报,1990年,12期,209页

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