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冠状动脉内置入国产支架的动物实验研究 被引量:3

The experimental study on intracoronary native metallic balloon-expandable stent
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摘要 目的观察国产支架置入大冠状动脉后的生物、血液相容性、支架开通率及其内皮化情况。方法将16个国产支架置入8只犬的冠状动脉内,分别于1、2、3、6个月进行观察。结果支架置入术后冠脉通畅,无明显狭窄。支架贴内膜良好,血管内腔表面光滑。术后2个月时支架覆盖的新生内膜最厚,其主要为平滑肌细胞和细胞外基质,未见明显炎性细胞浸润。支架置入1个月时,支架表面覆盖的内皮细胞排列不规则;置入2、3、6个月时,其沿血流方向排列规则。支架表面未见明显腐蚀。结论该国产支架置入后有良好的生物和血液相容性,理化性能稳定,迅速重新内皮化,有良好的开通率。 Objective To investigate the biocompatibility, bloodcompatibility, the patency rates and reendothelialization of native coronary metallic stent after being implanted into canine coronary artery.Methods Sixteen stents were implanted into eight canine coronary artery through femoral artery aproach.The pathological examination was taken at 1 to 6 months after coronary angiography.Results Thirteen stents were successfully implanted into target vessels of six dogs. Two dogs died of coronary spasm and acute stent thrombosis respectively. Coronary angiography demonstrated all vessles patency after intracoronary stenting (ICS). Macroscopy of stented arteries demonstrated complete incorporation of stent wires into the arterial wall and smooth vessle lumens. Light microscope demonstrated the neointima was the thickest at two months and consisted mainly of smooth muscle cells and extracellular matrix. The findings also included slight to moderate media oppression localized to areas of stent wires and no significant inflammatory raction. Scanning electron mcroscope demonstrated the endotheliocytes covering on stents oriented irregularly at one month and regularly at two and three as well as six months in the direction of blood flow. There was no significant erosion on stent wires.Conclusion The native balloon- expandable coronary metallic stems are promisint with good biocompatibility, biocompatibility and physicochemical stability after being implanted into canine coronary arteries. They can maintain high patency rates due to rapid reendothelialization.
出处 《中国介入心脏病学杂志》 2001年第1期50-52,共3页 Chinese Journal of Interventional Cardiology
基金 湖北省"九五"攻关项目资助
关键词 支架 冠状动脉造影 病理 动物实验 Coronary stent Canine Coronary angiography Pathologic examination
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参考文献3

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同被引文献27

  • 1刘建民,黄清海,许奕,洪波.血管内支架成形术治疗颅内宽颈动脉瘤及长期随访结果[J].中华神经外科杂志,2005,21(2):67-70. 被引量:62
  • 2张静波,吴中学,王忠诚,李佑祥,姜除寒,贺红卫,姜鹏,吕明,刘爱华,尹可,李险峰,赵均峰.带膜支架治疗出血性脑血管病初步经验[J].中华神经外科杂志,2006,22(8):457-459. 被引量:26
  • 3钟斌,殷跃辉.冠脉支架再狭窄的病理及防治[J].心血管病学进展,2007,28(3):392-397. 被引量:10
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  • 10张鑫,刘建民,周晓平,许奕,洪波,黄清海,张珑,佘家贵,赵瑞.血管内支架结合弹簧圈栓塞犬宽颈动脉瘤的病理学研究[J].中华神经外科杂志,2007,23(8):585-588. 被引量:28

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