部分性发作癫痫患者的认知功能损害与情绪障碍的分析

Analysis of cognitive function and emotional state in patients with partial epilepsy

目的:分析部分性发作癫痫患者的认知功能损害与情绪障碍的特点。方法:对78例部分性发作癫痫患者和60例性别、年龄和教育程度匹配的正常健康对照者组,采用韦氏数字广度测验(DST)、言语流畅性测验(VFT)量表进行认知功能评估,采用抑郁自评量表(SDS)和焦虑自评量表(SAS)进行情绪状态评估,并进行分析。结果:癫痫患者组的DST评分、VFT评分均较正常组低,差异具有统计学意义(p=0.000,p=0.000);癫痫患者组SDS评分和SAS评分均较正常组高,具有统计学差异(p=0.001,p=0.001);癫痫患者中认知功能及情绪障碍相关分析显示,DST评分与VFT评分,SDS评分与SAS评分均呈显著性正相关性(p<0.01)。结论:部分性发作癫痫患者存在记忆、语言方面的认知功能损害,并且存在明显的抑郁和焦虑情绪。神经精神量表是客观的评价癫痫患者神经心理状况的方便、有效手段。

Objective：To analysis the cognitive function and emotional state of the patients with partial epilepsy ,Methods：78 patients with partial epilepsy and 60 healthy controls with equivalent gender , age and education level were assessed by digital span test （ DST） and verbal fluency test （ VFT） of Wechsler adult intelligence scale （ WAIS） , self-rating depression scale （ SDS） , self-rating anxiety scale （SAS）.Results：Digital span test was significantly lower in patients compared with controls （p=0.000, p=0.000）.In verbal fluency test, the patients produce significantly less correct words than the controls （p=0.000）.The scores of SDS and SAS are significantly high-er in patients compared with controls（p=0.001,p=0.001）;The significant positive correlation were observed between scores of DST and VFT, the scores of SDS and SAS（P〈0.01）.Conclusion：The cognitive function of the partial epilepsy patients was impaired , with de-pression and anxiety as common symptoms in the patients .The neuropsychic scale might be the convenient and effective method to estimate the neuropsychic state of epilepsy patients .