乙肝肝硬化患者凝血及纤溶功能变化的临床意义

The clinical significance of in coagulation and fibrinolysis functions for patients with hepatitis B liver cirrhosis

目的探讨乙肝肝硬化患者的凝血及纤溶功能变化的临床意义。方法对正常人群和不同临床分期的肝硬化患者进行凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白质原(FIB)、血小板(PLT)血管性血友病因子(vwF),尿激酶型纤溶酶原激活物(uPA)、纤溶酶原激活物的抑制物(PAI)检测,结果应用SPSS13.0统计学软件进行统计分析。结果肝硬化患者PT、APTT、TT、uPA、PAI、vwF均明显高于健康对照组,PLT、FIB明显低于健康对照组。结论凝血及纤溶功能与肝硬化患者的疾病进展程度密切相关,对肝硬化患者出血的治疗和抢救有重要临床意义。

Objective To discuss the clinical significance of coagulation and fibrinolysis functions for patients with hepatitis B liver cirrhosis. Methods The prothrombin time （PT）,activated partial thromboplastin time （APTT）,thrombin time （TT）, fiber protein （FIB）, platelet （PLT）, von Willebrand factor （vwF）, urokinase type plasminogen activator （ uPA ） and plasminogen activator inhibitor （PAI） of normal people and patients with liver cirrhosis in different Clinical stages were detected,the SPSS13.0 statistical software was used for statistical analysis. Results The PT,APTT,TT,uPA,PAI and vwF of patients with liver cirrhosis were all significantly higher than those of the healthy control group,while the PLT and FIB were significantly lower than those of the healthy control group. Conclusion The coagulation and fibrinol- ysis functions are closely related to the disease progress for patients with liver cirrhosis,which has important clinical significance for the treatment and rescue of bleeding for patients with liver cirrhosis.