不同方案联合液体疗法治疗小儿轮状病毒感染性腹泻的疗效和安全性比较

Comparison on the efficacy and safety of different scheme combined with fluid therapy in children withrotavirus diarrhea

目的探讨西咪替丁和干扰素联合补锌治疗小儿轮状病毒感染性腹泻的疗效和安全性。方法选取轮状病毒肠炎患儿108例,随机分为两组,每组54例。对照组患儿使用西咪替丁和干扰素进行治疗,观察组在对照组的基础上增加补锌治疗,对比两组患儿恢复情况、疗效和不良反应。结果观察组脱水纠正时间、大便恢复正常时间和体温恢复正常时间明显短于对照组,差异有统计学意义(P<0.05);观察组总有效率94.44%明显高于对照组的81.48%,差异有统计学意义(P<0.05);观察组不良反应发生例数与对照组比较,差异无统计学意义(P>0.05)。结论西咪替丁和干扰素联合补锌治疗小儿轮状病毒感染性腹泻的临床效果好,患儿恢复快,不良反应少。

Objective To investigate the efficacy and safety of cimetidine and interferon combined with zinc treatment in children with rotavirus diarrhea. Methods Selecting 108 cases of children with rotavirus enteritis and randomly dividing them into two groups, 54 cases for each group. Patients in the control group using cimetidine and interferon treatment, observation group were based on the control group and increase of zinc treatment, compared two groups of recovery, curative effect and adverse reaction. Results The observation group after treatment in children dehydration correcting time, defecate normal time and the temperature recovery time compared with the control group, the difference was statistically significant（P〈0.05）;efficiency of patients in observation group（94.44%） was significantly higher than control group（81.48%）, the difference was statistically significant（P〈0.05）; observation group the number of adverse reaction compared with the control group, the difference is not statistically significant（P〉0.05）. Conclusion Clinical effect of cimetidine and interferon combined with zinc treatment in children with rotavirus diarrhea is good, with fast recovery and less adverse reaction.