通心络胶囊对冠心病患者血清同型半胱氨酸的影响

Effect of Tongxinluo capsule on serum homocysteine of CHD patients

目的探讨通心络胶囊对冠心病(CHD)患者血清同型半胱氨酸(Hcy)的影响。方法将90例CHD伴高Hcy患者随机分为治疗组和对照组各45例,2组均给予口服拜阿司匹林、硝酸酯类、他汀类等药物治疗,治疗组在此基础上,给予通心络胶囊4粒,每天3次;对照组在此基础上加用叶酸5mg/d、维生素B12500μg/d。2组均治疗8周。观察2组心绞痛症状缓解情况、心电图和血清Hcy水平改善情况。结果 2组心绞痛症状缓解率、心电图改善率和血清Hcy水平改善率均高于对照组,差异有统计学意义(P<0.05)。结论通心络胶囊能够改善冠心病患者的高Hcy血症,并能显著改善患者的心电图和缓解临床症状。

Objective To explore the effects of Tongxinluo capsule on coronary heart disease（CHD）patients serum homocysteine（Hcy）. Methods 90 cases of CHD patients with high Hcy were randomly divided into the treatment group and control group,each of 45 cases. Both groups were given oral aspirin,nitrates,statins for treatment. The treatment group was giv-en Tongxinluo capsule 4 pills,TID for treatment based on the routine drugs. The control group was given folic acid（5mg/ d）, vitamin（B12 500μg/ d）based on the routine drugs. Both groups were treated for 8 weeks. The angina pectoris symptom remis-sion,electrocardiogram and serum Hcy level were observed. Results After 8 weeks treatment,the angina pectoris symptom re-mission,electrocardiogram and serum Hcy level of the treatment group were all better than those of the control group,and the differences were statistically significant（P ﹤ 0. 05）. Conclusion Tongxinluo capsule can improve the high level of Hcy in pa-tients with CHD,and it can improve the patient′s ECG and alleviate clinical symptoms.