埃索美拉唑治疗老年性胃溃疡的临床疗效分析

Clinical Efficacy of Esomeprazole in the Treatment of Senile Gastric Ulcer

目的分析埃索美拉唑治疗老年性胃溃疡的临床疗效。方法选取本院2012年10月—2013年收治的58例老年性胃溃疡患者,随机分为对照组及观察组,各29例,对照组患者给予奥美拉唑治疗,观察组患者给予埃索美拉唑治疗,比较两组患者的临床疗效。结果观察组患者的临床总有效率93.10%(27/29)高于对照组71.41%(21/29),差异有统计学意义(P<0.05);观察组患者的幽门螺杆菌(Hp)根除率89.66%(26/29)高于对照组患者的Hp根除率68.97%(20/29),差异有统计学意义(P<0.05);观察组患者不良反应率6.90%(2/29)低于对照组患者不良反应率13.79%(4/29),差异有统计学意义(P<0.05)。结论老年性胃溃疡患者采用埃索美拉唑治疗的疗效显著,且不良反应少,具有较高的安全性。

Objective To analyze clinical effect of esomeprazole in the treatment of senile gastric ulcer. Methods 58 patients of senile gastric ulcer in our hospital from October 2012 to October 2013,which were randomly divided into control group and observation group,29 cases in each group,control group was treated with Omeprazole,observation group was treated with esomeprazole therapy,the clinical efficacy of two groups were compared. Results Total effective rate of observation group was 93. 10% （27 / 29）,which was higher than 71. 41% （21 / 29）of control group,the difference was statistically significant （P 〈 0. 05）;Helicobacter pylori（Hp）eradication rate of observation group was 89. 66% （26 / 29）,which was higher than 68. 97% （20 / 29）of control group,the difference was statistically significant（P 〈 0. 05）;Adverse reaction rate of observa-tion group was 6. 90% （2 / 29）,which was lower than 13. 79% （4 / 29）of control group,the difference was statistically signif-icant（P 〈 0. 05）. Conclusion Esomeprazole treating senile gastric ulcer patients,has significant efficacy,and less adverse reaction,high security.