复方蒌薤合剂对鼠动脉粥样硬化血管内皮功能的影响

Effects of TCM Louxie mixture on vascular reactivity in atherosclerosis rats

目的:探讨瓜蒌薤白类方(自拟复方萎薤合剂)对实验性动脉粥样硬化(amerosclerosis,AS)大鼠血管内皮功能的影响。方法:采用高脂饲料喂养wister大鼠制备动脉粥样硬化模型。大鼠按体重进行随机分组设计,分为4组,各10只,正常对照组(A组)、高脂模型组(B组)、高脂瑞舒伐他汀治疗组(C组)和高脂复方萎薤合剂治疗组(D组),共饲养干预10周。在0周和10周末取大鼠血浆,测定内皮素(ET-1)、一氧化氮(NO)和一氧化氮合酶(NOS)。结果:B组0周与10周时血浆NO、NOS水平明显降低,ET-l水平明显上升。瑞舒伐他汀和复方蒌薤合剂均可提高血浆NO和NOS水平,降低ET-1水平。结论:中药复方蒌薤合剂通过升高血浆NO、NOS水平,降低ET-1水平,对内皮功能有保护作用。

Objective：To investigate effects of TCM Louxie mixture on vascular reactivity in atherosclerosis rats. Methods：Forty male rats were randomly divided into four groups：the control group （A group, n=10） was fed with normal diet;the model group （B group, n=10）, atorvastatin treated group （C group, n=10）, TCM Louxie mixture treated group （D group, n=10）. Serum endothelin-1 （ET-1）, nitric oxide （NO） and nitric oxide syntheses （NOS） were observed in different groups before and after the treatment. Results：Rosuvastatin and Louxie mixture can improve the level of plasma NO and NOS, and lower the level of ET-1. Conclusion：TCM Louxie mixture can improve endothelial function in atherosclerosis rats.