红景天洋参片缓解体力疲劳的实验研究

Investigation of alleviating physical fatigue effect of rhodiola rosea ginseng tablets

目的研究红景天洋参片缓解体力疲劳作用。方法经口给予健康ICR小鼠0、200、400、1 200mg/kg剂量的红景天洋参片30d后,分别进行负重游泳实验、肝糖原测定、血乳酸测定和血清尿素氮测定。结果低剂量组小鼠负重游泳时间比对照组延长,差异有统计学意义(P<0.01);中、低剂量组小鼠运动前后3个时间点血乳酸曲线下面积均低于对照组,差异具有统计学意义(P<0.05);低剂量组小鼠运动后血清尿素氮值低于对照组值,差异有统计学意义(P<0.01)。结论红景天洋参片在本实验条件下具有缓解体力疲劳作用。

Objective To study alleviating physical fatigue effect of rhodiola rosea ginseng tablets.Methods Healthy ICR mice were treated with 0,200,400,1 200mg/kg dose of rhodiola rosea ginseng tablets by oral approach for 30d.All mice were subjected to loading swimming test and analysis of hepatic glycogen,serum lactic acid and serum urea nitrogen.ResultsLoading swimming time of mice in low dose group was longer than that of control group,with significant difference（P 0.01）.Compared to control group,mice in middle dose and low dose group showed fewer areas under curve of serum lactic acid concentration at 3time points before and after exercise,with significant difference（P〈.05）.After exercise,mice in low dose group showed lower serum urea nitrogen concentration than that of control group,with significant difference（P〈.01）. Conclusion Rhodiola rosea ginseng tablets had alleviating physical fatigue effect under experimental condition.