Hadamard技术在不均匀场中获取高分辨核磁共振谱的应用

Application of Hadamard encoding technology for achieving high-resolution NMR spectroscopy in inhomogeneous fields

核磁共振(NMR)谱广泛应用于化学,生物和材料科学等领域。分子间多量子相干技术(iMQCs)可以有效地在不均匀磁场中获得高分辨NMR谱,但是该方法获取高分辨谱通常需要较长的数据采集时间,在很大程度上限制了它的应用。Hadamard技术具有时间短和信噪比高的特点,该技术可以较大地缩短不均匀场下采集高分辨NMR谱的时间,因而扩展并增强iMQCs方法在不均匀场下获取高分辨谱的实用性。总结了近几年Hadamard技术结合iMQCs方法在不均匀磁场中获取高分辨NMR谱的基本原理和应用,并对其优缺点做了详细的分析和讨论。

Nuclear magnetic resonance（NMR） spectroscopy has been widely used in chemistry,biology and material science. Intermolecular multiple quantum coherences（iMQCs）has been proven to be effective in retrieving high-resolution spec-tra in inhomogeneous fields. However,relatively long acquisition time limits its practical applications. Hadamard encoding tech-nology can be used to shorten the acquisition time and increase the signal to noise ratio. In this paper,the principle of achieving high-resolution spectroscopy in inhomogeneous fields by combining Hadamard encoding technology with iMQCs is summarized in this paper. Advantages and disadvantages of this method are analized and discussed.