疏血通联合依达拉奉治疗脑梗死合并糖尿病临床研究

Clinical Study on Cerebral Infarction Combined with Diabetes Treated by Shu Xue Tong Combined with Edaravone

目的:观察疏血通联合依达拉奉治疗脑梗死合并糖尿病的临床疗效。方法:87例随机分为单纯组45例和联合组42例,单纯组给予依达拉奉治疗,联合组给予疏血通及依达拉奉治疗,另两组均给予常规抗感染、神经康复及降糖等治疗。观察两组临床有效率、神经功能改善、凝血功能状况、血液流变学状况及不良反应。结果:治疗4周后,总有效率联合组95.24%,单纯组82.22%,两组比较有统计学意义(P<0.05)。两组治疗2、4周后神经功能均有明显改善,联合组NIHSS评分显著低于单纯组(P<0.05)、ADL评分显著高于单纯组(P<0.05)。联合组治疗后PT及APTT均明显延长、AT-Ⅲ显著提高,与单纯组比较具有统计学意义(P<0.05)。联合组低切全血黏度、血浆黏度及红细胞聚集指数改善程度均显著优于单纯组(P<0.05)。结论:疏血通联合依达拉奉治疗脑梗死合并糖尿病可明显改善神经功能、凝血功能及血液流变学,提高临床疗效。

Objective： to study the effect of combined usage of Edaravone and ShuXieTong in treatment of cerebral infarction with diabetes mellitus.Methods ： 87 cases of cerebral infarction patients with diabetes mellitus were randomLy divided into pure group （45 cases ） and the combined group （42 cases ） .The pure group was given edaravone in treatment, and the combined group was given ShuXieTong and edaravone in treatment.Both of the groups were given routine antinfection, neurological rehabilitation, hypoglycemic therapy, etc.View the clinical effectiveness of two groups, nerve function, blood coagulation function improvement, the condition of blood rheology and adverse reactions.Results ： after 4 weeks of treatment, the total effective rate of combined group was 95.24%, significantly higher than that of pure group which was 82.22%.The difference was statistically significant （ P〈0.05 ） .2 or 4 weeks after treatment, the nerve function of patients of both groups were improved significantly.NIHSS score of combined was significantly lower than pure group （P〈0.05） and ADL score of combined group significantly higher than that of pure group （ P〈0.05 ） .After treatment, PT and APTT of combined group were significantly prolonged, and the AT - Ⅲ of combined group was also increased significantly.There is a significant difference between the result of pure group and combined group （ P〈0.05 ） .And the low shear whole blood viscosity, plasma viscosity and erythrocyte aggregation index of combined group were significantly better than that of pure group （ P〈0.05 ） .Conclusion ： combined use of edaravone and ShuXieTong in treatment of cerebral infarction with diabetes mellitus patients can significantly improve the nerve function, blood coagulation function and blood theology, and clinical effectiveness.