CD147在胃肠道癌中的表达及意义

EXPRESSION AND SIGNIFICANCE OF CD147 PROTEIN IN GASTROINTESTINAL CANCER

目的:探讨CD147在胃肠道癌中的表达情况和意义。方法:应用免疫组化法检测胃肠道癌(n=996)和癌旁正常黏膜(n=110)中CD147的表达情况,并分析CD147表达与胃肠道癌临床病理特征和预后的关系。结果:胃肠道癌CD147的阳性表达率明显高于正常黏膜(P<0.01)。胃肠道癌CD147的表达与年龄、肿瘤大小、静脉侵袭和淋巴管侵袭有关(P<0.05);与性别、淋巴结转移及UICC分期无关(P>0.05)。Kaplan-Meier曲线显示CD147表达与患者的预后无明显相关性(P>0.05)。结论:CD147参与胃肠道癌的发生和局部浸润,可作为反应胃肠道癌病理生物学行为的有效分子标志。

Objective：To investigate the expresion and significance of CD147 in gastrointestinal cancer. Methods：Immunohistochemical staining was used to detect the expression of CD147 in 996 cases gastrointestinal cancer and 110 cases para-carcinoma normal mucosa, and analyzed the relationships between CD147 expression and clinicopathologic features and prognosis of gastrointestinal cancer.Results：The expression of CD147 in gastrointestinal cancer was obviously higher than that in normal mucosa （P〈0.01）. In gastrointestinal cancer, the CD147 expression was nothing to do with sex, lymph node metastasis and UICC stage （P〉0.05）; but was associated with age, tumor size, venous invasion and lymphatic vessel invasion （P〈0.05）. Kaplan-Meier curve showed CD147 expression had no signiifcant correlation with the prognosis of gastrointestinal cancer patients （P〉0.05）.Conclusions： CD147 participates the development of gastrointestinal cancer, and can be acted as effective molecular marker to reveal the biological behavior of gastrointestinal cancer.