Pokemon、c-myc在结直肠癌中的表达及意义

EXPRESSION AND CLINICAL SIGNIFICANCE OF POKEMON AND C-MYC IN COLORECTAL CANCER

目的:探讨结直肠癌组织Pokemon和c-myc蛋白表达的变化和意义。方法:SP免疫组化法检测60例结直肠癌组织和癌旁正常组织Pokemon和c-myc蛋白的表达情况。结果:结直肠癌组织Pokemon和c-myc蛋白的阳性表达率均明显高于正常组织(P<0.01);结直肠癌组织Pokemon和c-myc蛋白的阳性表达与分化程度、Dukes分期和淋巴结转移有关(P<0.01,P<0.05);结直肠癌组织中,Pokemon和c-myc蛋白的表达呈显著正相关(r=0.615,P<0.05)。结论:Pokemon和c-myc对结直肠癌的诊断和预后评判具有一定的价值。

Objective： To investigate the expression and clinical significance of Pokemon and c-myc in human colorectal cancer.Methods： SP immunohistochemical staining was used to detect the expression of Pokemon and c-myc in 60 cases colorectal cancer and matched para-carcinoma tissues.Results：The positive expression rate of Pokemon and c-myc in colorectal cancer were obviously higher than that in normal tissue （P〈0.01）. In colorectal cancer, the positive expression of Pokemon and c-myc were related with differentiation degree, Dukes stage and lymph node metastasis （P〈0.01,P〈0.05）. The positive expression of Pokemon in colorectal cancer was positively correlated with c-myc expression （r=0.615,P〈0.05）. Conclusions： Pokemon and c-myc have certain value for diagnosing and prognosis of colorectal cancer.