摘要
[目的]观察柴胡疏肝散联合西药治疗抑郁型冠心病疗效。[方法]使用随机平行对照方法,将49例住院患者按简单随机法分为两组。对照组24例扩冠、抗血小板、抗凝、β受体阻滞剂、他汀类药物及钙离子拮抗剂等。治疗组25例柴胡疏肝散(陈皮、柴胡各15g,枳实、芍药各10g,炙甘草5g,香附、川芎各10g),水煎服,1剂/d,水煎200mL,分早晚口服;西药治疗同对照组。连续治疗4周为1疗程。观测临床症状、心绞痛发作情况、健康问卷(PHQ)指标、不良反应。治疗1疗程,判定疗效。[结果]抑郁症状:治疗组显效8例,有效11例,无效6例,总有效率76%。对照组显效1例,有效8例,无效15例,总有效率37.50%。治疗组疗效优于对照组(P<0.01)。心绞痛症状:治疗组显效7例,有效15例,无效3例,总有效率88.00%。对照组显效2例,有效13例,无效9例,总有效率62.50%。治疗组疗效优于对照组(P<0.05)。[结论]柴胡疏肝散联合西药治疗抑郁型冠心病疗效满意。
[Objective]To observe the clinical effect of Bupleurum Liver-Coursing Powder with western medicine on depressive coronary heartdisease.[Method]A randomized,parallel-controlled trial was conducted,atotal of 49 in-patients were classified into two groups. 24patients in the control group were given standard medicineincluding coronary artery dilation,anti-platelet,anti-coagulation,β-blocker,statins and calcium antagonist,etc.25 patients in the treatment group,besides standardadministration,were added Bupleurum Liver-Coursing Powder(pericarpium citri reticulatae and Radix Bupleuri 10g each,Immature Bitter Orange and Chinese herbaceous peony 10g each,honey-fried licorice root 5g,rhizoma cyperi and Ligusticumwallichii 10g each),which was decocted in 200mL water for oraldose,taken twice a day. The treatment last 4 weeks. Then clinicaleffect,PHQ and adverse reactions were observed.[Result]For depressive symptoms,in treatment group,8 werestrongly effective,11 were effective,6 were ineffective andeffective rate was 76%;in control group,1 were stronglyeffective,8 were effective,15 were ineffective and effective ratewas 37.5%. The effect of treatment was better than controlgroup(P〈0. 01). For angina,in treatment group,7 were stronglyeffective,15 were effective,3 were ineffective and effective ratewas 88%;in control group,2 were strongly effective,13 wereeffective,9 were ineffective and effective rate was 62.5%. Theeffect of treatment was better than control group(P〈0. 05).[Conclusion]Bupleurum Liver-Coursing Powder with western medicinehas satisfactory effect on depressive coronary heart disease
出处
《实用中医内科杂志》
2014年第3期45-47,共3页
Journal of Practical Traditional Chinese Internal Medicine
关键词
抑郁型冠心病
胸痹
柴胡疏肝散
健康问卷(PHQ)
中西医结合治疗
随机平行对照研究
Depressive coronary heartdisease
Thoracic obstruction
Bupleurum Liver-Coursing Powder
PHQ
Conbined treatment of traditional Chinese medicine and western medicine
Randomized parallel contrast study