瑶药权提汤联合肝动脉化疗栓塞治疗原发性肝癌随机平行对照研究

Yao Medicine Quanti Tang Combined With TACE In Treating Primary Liver Cancer Randomized Parallel Controlled Study

[目的]观察瑶药权提汤联合介入治疗原发性肝癌疗效。[方法]使用随机平行对照方法,将68例住院患者按抽签法随机分为两组。对照组34例肝动脉化疗栓塞（TACE）治疗,Seldinger法经股动脉穿刺插管至肝固有动脉或分支后注入碘海醇造影,观察肿瘤染色情况,确定注入药物和剂量;顺铂（DDP）40mg＋表阿霉素（EPI）40mg与超液化碘油10-30mL充分混合成乳剂缓缓注人,1-2mm明胶海绵栓塞供血动脉;术后常规补液、对症治疗。治疗组34例瑶药权提汤（夏枯草20g,田基黄、生牡蛎各30g,山慈菇12g,半边莲、薏米各30g,生姜9g,马齿苋、叶下珠、水杨梅各30g）,1剂/d,水煎250mL,早晚温,TACE前1周,TACE后服用;TACE治疗同对照组。连续治疗40d为1疗程。观测生活质量评分、实体瘤疗效、药物毒副反应。[结果]Karnofsky评分改善治疗组优于对照组（P〈0.05）,实体瘤大小变化两组无明显差异（P〉0.05）,药物毒副反应治疗组优于对照组（P〈0.05）。[结论]瑶药权提汤联合介入治疗原发性肝癌,能明显提高患者生活质量,且在减轻TACE后毒副反应有明显优势,值得推广。

[ Objective ] To observe the clinical curative effect of Yao medicine Quanti Tang combined with TACE in treating primary liver cancer. [ Method ] Using random parallel control method, 68 cases of hospitalized patients were randomly divided into two groups according to the draw method. Control group of 34 cases of hepatic artery embolism chemotherapy （ TACE ） with conventional treatment, the Seldinger method via femoral artery puncture intubation to proper hepatic artery or its branch after injection of iodine alcohol angiography, observe the tumor staining situation, determine the injection of drugs and dosage. Cisplatin （ DDP ） 40 mg ＋ table adriamycin （ EPI ） 40 mg and ultra liquefied iodine oil 10 - 30 mL note people slowly mix into emulsion, in l - 2 mm blood supply artery of gelatin sponge embolism. Postoperative routine rehydration, symptomatic treatment. The control group after interventional conventional rehydration, symptomatic treatment. Treatment group of 34 cases of Quanti Tang, Xiagucao 20 g, Tianjihuang, Shengmuli each 30g, Shancigu 12g, Banbianlian, Yimi each 30 g, Shengjiang 9 g, Machixian, Yexiazhu, Shuiyangmei each 30g . 1 / d, decoction of 250 ml, morning and evening temperature. TACE with the control group. Continuous treatment of 40 d of 1 course of treatment. Observation life quality score, solid tumor curative effect before and after the treatment, drug adverse reaction. [ Results ] Karnofsky score to improve the treatment group is better than that of control group （ P 〈 0.05 ）, solid tumor size change in treatment group and control group no significant difference（ P 〉 0.05 ）, drug adverse reaction in treatment group is better than that of control group（ P 〈 0.05 ）. [ Conclusion ] The Quanti Tang combined interventional treatment for primary liver cancer curative effect significantly, can significantly improve the patients quality of life, reduce the content of AFP, and in reducing the adverse reaction after conventional TACE has obvious advantages, is worth nromotina.