醒脑静注射液联合西药治疗急性重型颅脑损伤随机平行对照研究

Refreshing Static Injection on Acute Severe Craniocerebral Injury Random Parallel Control Study

[目的]观察醒脑静注射液联合西药治疗急性重型颅脑损伤疗效。[方法]使用随机平行对照方法,将36例住院患者按掷骰子法随机分为两组。对照组18例常规治疗,开颅血肿清除加去骨瓣减压术,术后转ICU监护治疗,甘露醇脱水、抗感染、器官功能支持、营养支持等。治疗组18例30mL醒脑静注射液＋100mL盐水,1次/d,静滴;西药治疗同对照组。连续治疗7d为1疗程。观测临床症状、血清NSE、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组痊愈12例,显效3例,有效2例,无效1例,总有效率94.44%。对照组痊愈6例,显效3例,有效3例,无效6例,总有效率66.67%。治疗组疗效优于对照组（P〈0.05）。两组血清NSE水平在术后1-5d内效果显著（P〈0.05）。[结论]醒脑静注射液联合西药治疗急性重型颅脑损伤效果显著,值得推广。

[ Objective ] To observe the refreshing static injection on acute severe craniocerebral injury of serum levels affect curative effect. [ Methods ] Using random parallel control method, the 36 cases of hospitalized patients were randomly divided into two groups according to roll the dice method. The control group 18 cases with conventional treatment, hematoma clear add to bone flap craniotomy decompression, postoperative ICU care treatment, mannitol dehydrate, anti-infection, organ function support, nutritional support treatment. 18 cases in treatment group 30 ml refreshing static injection ＋ 100 ml saline, l/d, static drops. Western medicine treatment with the control group. Continuous treatment of 7 d for 1 course of treatment. Observation of clinical symptom, serum NSE, adverse reactions. Continuous treatment 2 period of treatment, judge curative effect. [ Results ] The treatment group 12 cases recovered, 3 cases were markedly effective, effective in 2 cases, 1 had no effect, the total effective rate was 94.44%. Control group cure 6 cases, 3 cases were markedly effective, effective in 3, 6 no effect, the total effective rate was 66.67%. The treatment group curative effect is better than that of control group （ P〈0.05 ） .Two groups of serum NSE levels in postoperative 1 - 5d effect significantly （ P〈0.05 ）. [ Conclusion ] Wake up static injection on acute severe craniocerebral injury influence effect is remarkable, is worth promoting.