氢氯吡格雷联合阿司匹林治疗进展型脑梗死临床观察

Clinical Study of Clopidogrel Combined with Aspirin in the Treatment of Progressive Cerebral Infarction

目的:探讨氢氯吡格雷联合阿司匹林治疗进展型脑梗死的疗效。方法:180例进展型脑梗死患者随机分为两组,对照组90例给予阿司匹林片100 mg,po qd,试验组90例给予硫酸氢氯吡格雷片75 mg,po qd,阿司匹林片100 mg,po qd。15 d后观察两组患者临床疗效,比较两组患者神经功能改善情况和药品不良反应。结果:治疗后,试验组神经功能缺损评分较前降低(P<0.05),且明显低于同期对照组(P<0.05)。试验组总有效率88.9%,高于对照组的66.7%(P<0.05)。两组不良发应发生率差异无统计学意义(P>0.05)。结论:氢氯吡格雷联合阿司匹林治疗进展型脑梗死效果显著,能显著促进患者神经功能的恢复。

Objective：To explore the curative effect of clopidogrel combined with aspirin on progressive cerebral infarction. Methods： 180 cases of the progressive cerebral infarction patients were randomly divided into two groups. 90 cases in the control group were given aspirin tablet 100mg,po qd, and 90 patients in the experimental group, given clopidogrel tablet 75mg,po qd combined with aspirin treatment. The differences in clinical efficacy were observed in the two groups and the nerve function and adverse drug reaction（ADR） were evaluated. Results： The total effective rate in the ex- perimental group was 88.9%, higher than 66.7% of the control group , and the difference was statistically significant （P 〈 0.05 ）. The treatment satisfaction rate of the experimental group was 84.4%, higher than 62.2% of the control group , and the difference was significant （P 〈 0.05 ）. After the treatment, the neural function defect score of the experimental group was decreased, and was lower than that of the control group and the difference was statistically significant （P 〈 0.05 ）. No significant difference in the rate of ADR between the two group（ P 〈 0.05 ）. Conclusion： Clopidogrel combined with aspirin had its remarkable effect on the treatment of progressive cerebral infarction, and a combination of the two had high clinical efficiency, which could significantly promote the neurological recovery.