甲氨蝶呤联合米非司酮治疗异位妊娠疗效观察

Observation of Methotrexate and Mifepristone in the Treament of Ectopic Pregnancy

目的:观察甲氨蝶呤联合米非司酮治疗异位妊娠的临床疗效。方法:58例异位妊娠患者按入院前后次序分为观察组及对照组各29例。对照组予甲氨蝶呤50 mg·m-2,im bid;观察组在对照组基础上,加用米非司酮片50 mg,po bid。两组疗程均为3 d。治疗后比较两组治愈率、二次用药率及不良反应发生率。结果:观察组治愈率为93.1%,高于对照组的69.0%(P<0.05);二次用药率为10.3%,明显低于对照组的48.4%(P<0.05);两组不良反应发生差异无统计学意义(P>0.05)。结论:甲氨蝶呤联合米非司酮治疗异位妊娠效果确切,能明显降低二次用药率,值得临床推广使用。

Objective：To observe the application effect of methotrexate and mifepristone on ectopic pregnancy. Methods：58 cases of ectopic pregnant patients were treated in our hospital from January 2010 to January 2013 according to admission order and divided into study group and control group with 29 cases in either group. The control group was treated with methotrexate intramuscular injection, and based on the treatment of the control group, the study group was treated with mifepristone. At the end of the treatment, the cure rate , secondary compliance rate and adverse reaction rate were compared between the two groups. Results： After the treatment, the cure rate of the study group was 93.1% higher than those of the control group （69%） . The difference was statistically significant （P 〈 0.05 ）： The secondary compliance rate of the study group was only 10.3%, significantly lower than 48.4% of the control group, and the difference was statistically significant （P〈0.05）. The incidence rate of adverse reaction in the study group was 55.2% and 51.7% in the control group, and there was no significant difference （ P 〉 0.05 ）. Conclusion： Methotrexate and mifepristone had their accurate efficacy in the treatment of ectopic pregnancy. They could reduce the secondary compliance rate, and the burden of the patients and their family members. The treament is worthy of clinical use.