纳络酮抢救急性中毒患者的效果及对患者清醒时间的影响

Effect of Naloxone on the Treatment of Acute Poisoning Patients and the Influence of Awake Time Patients

目的：探讨纳络酮在各种急性中毒患者抢救中的临床效果。方法：回顾性分析我院急诊科2009年10月~2012年10月收治的320例急性中毒患者的病例资料,其中急性乙醇中毒125例、急性一氧化碳中毒137例、急性安眠药中毒30例、急性有机磷中毒28例。观察组选择采用纳络酮治疗的165例患者,对照组为采用常规治疗的155例患者,对比两组患者临床效果、清醒时间及不良反应发生情况。结果：观察组临床效果显著优于对照组,清醒时间较对照组有明显缩短,两组差异有统计学意义（P〈0.05）;两组患者用药过程中均未见明显不良反应发生。结论：纳络酮应用于乙醇、一氧化碳、安眠药、有机磷等急性中毒患者有较好的临床效果,值得在临床上推广使用。

Objective ：To investigate the clinical effects of naloxone on the treatment of acute poisoning patients. Methods：320 cases of acute poisoning patients were retrospectively analyzed in our hospital emergency department from October 2009 to October 2012 and they were 125 cases of acute alcoholism, 137 cases of acute carbon monoxide poisoning, 30 cases of acute hypnotic poisoning, and 28 cases of acute organic phosphorus poisoning. 165 cases as the treatment group were treated with naloxone and 155 cases as the control group were conventionally treated. The clinical effect, recovery time and adverse reaction of the two groups were compared. Results： The clinical effect of the treatment group was significantly better than that of the control group, and the recovery time was significantly shorter than that of the control group. There was significant difference between the two groups （ P 〈 0.05 ）. The two groupss had no obvious adverse reactions in the medication proces. Conclusion：The naloxone applied to ethanol, carbon monoxide, sleeping pills, organic phosphorus poisoning patients had good clinical effect and it is worthy of promotion in clinical use.