金胃泰联合Hp根除三联疗法治疗胃十二指肠溃疡疗效观察

Effect of Jinweitai Combined with Hp Eradication Triple Therapy in the Treatment of Gastric Ulcer

目的:探讨金胃泰联合Hp根除三联疗法治疗胃十二指肠溃疡的疗效及安全性。方法:140例胃十二指肠溃疡患者随机分为两组,A组给予克拉霉素、阿莫西林、果胶铋、泮托拉唑根除幽门螺杆菌(Hp)三联疗法治疗;B组在A组基础上,加用金胃泰胶囊0.3 g,po,tid。两组均持续治疗8周,观察并比较疗效。结果:B组治疗总有效率、Hp根除率均高于A组(P<0.05);治疗后B组轻度炎症、无中性粒细胞浸润比例高于A组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:在常规Hp根除三联疗法基础上加用金胃泰治疗胃十二指肠溃疡,可提高Hp根除率,促进炎症消除,且不良反应少。

To investigate the effect and safety of Jinweitai combined with triple therapy in the treatment of gastric ul- cer. Methods ： Totally 140 cases of gastric ulcer patients were randomly divided into two groups, group A was given clarithromycin, amoxicillin, bismuth pectin and pantoprazole in Hp eradication triple therapy, while group B was additionally given 0.3g Jinweitai oral- ly, po, tid. The treatment course was 8 weeks. The effect was observed and compared. Results： Both the total effective rate and lip e- radication rate of group B were higher than： those of group A, the rate of mild inflammation and non-neutrophils infiltration after the treatment in group B were higher than those in group A （P 〈 0.05 ）. The incidence of adverse reactions in the two groups was without statistical significance （P 〉 0.05）. Conclusion： Base on the conventional Hp eradication triple therapy, Jinweitai can increase Hp e- radication rate and promote inflammation eliminate without extra adverse reactions in the treatment of gastric ulcer.