乌司他丁联合生长抑素治疗急性重症胰腺炎疗效观察

Curative Effect Observation of Ulinastatin Combined with Somatostatin in the Treatment of Acute Severe Pancreatitis

目的:研究乌司他丁联合生长抑素治疗急性重症胰腺炎的临床疗效。方法:130例急性重症胰腺炎患者随机分为两组各65例。在常规治疗基础上,对照组患者给予生长抑素3 mg+0.9%氯化钠注射液250 ml,ivd,bid,观察组患者在对照组基础上加用乌司他丁10万u+0.9%氯化钠注射液250 ml,ivd,tid。两组疗程均为10 d。比较治疗后两组患者的临床症状消失时间、呼吸及心率恢复正常时间、住院时间、血尿淀粉酶和临床总有效率。结果:观察组患者的临床症状消失时间、呼吸心率恢复正常时间、住院时间等均明显短于对照组患者(P<0.05),两组血尿淀粉酶恢复时间差异无统计学意义(P>0.05),观察组总有效率为95.38%,对照组总有效率为73.84%,两组比较,差异有统计学意义(P<0.05)。结论:乌司他丁联合生长抑素治疗急性重症胰腺炎疗效显著,可有效改善患者的临床症状,缩短病程,值得临床推广使用。

To observe the clinical effect of ulinastatin combined with somatostatin in the treatment of acute severe pan- creatitis. Methods： Totally 130 cases of severe acute pancreatitis patients were randomly divided into two groups with 65 cases in each. The control group was given the routine treatment and 3mg somatostatin in 250ml sodium chloride injections, ivd, bid, and the treatment group was given 10ku ulinastatin in 250ml sodium chloride injections additionally, ivd, bid. After the 10-day treatment, the clinical symptom disappearance time, the recovery time of respiratory and heart rate, length of stay, blood and urine amylase, and clin- ical total effective rate were compared between the two groups. Results： The symptom disappearance time, recovery time of respiratory and heart rate and length of stay in the treatment group were all shorter than those in the control group （P 〈 0.05 ）. The recovery time of serum and urine amylase in the two groups was without significant difference （P 〉 0.05 ）. The total effective rate of the treatment group was 95.38%, while that of the control group was 73.84% with significant difference （ P 〈 0.05 ）. Conclusion： The application of ulinastatin in the treatment of severe acute pancreatitis shows obviously curative effect, which can effectively improve the clinical symptoms and shorten the course of disease, and is valuable in clinical use.