基于ReHo方法的精神分裂症患者攻击行为的静息态fMRI研究

Resting fMRI study of schizophrenic patients with aggressive behavior： based on ReHo analysis

目的 通过相关脑区结构与功能的对照研究,探讨精神分裂症患者暴力攻击行为的神经认知障碍基础.方法 对有、无攻击行为的精神分裂症患者和健康对照三组人群各21例进行静息状态下脑功能性磁共振成像（fMRI）,运用局域一致性（ReHo）分析方法进行数据分析处理,比较三组之间的差异.结果 与健康对照组相比,精神分裂症非攻击组在左侧额叶、中央前回、中央后回、两侧丘脑、右侧脑岛等脑区的局部一致性存在异常;而精神分裂症攻击组除表现上述脑区局部一致性异常,还表现出两侧前扣带回、左侧海马旁回等边缘系统脑区局部一致性的异常.结论 额叶、丘脑、中央前回、中央后回及脑岛等脑区的异常可能与精神分裂症症状以及攻击行为均有关,而边缘系统等脑区的异常可能与精神分裂症的攻击行为存在特异性联系.

Objective To explore the potential anatomical and functional basis for neuro--cognitive deficits of aggression in schizophrenic patients using resting state fMRI activity in relevant brain areas. Methods Sixty--three cases were divided into three groups （21 in each group）. These groups were schizophrenia patients with aggression （AS）, schizophrenia patients without aggression （NAS）, and healthy control （H）. Regional Homogeneity （ReHo） method was used to analyze resting state fMRI data. The differences of the ReHo values between AS /NAS and from the H group were detected. Results Compare with the healthy control, both AS and NAS groups show abnormal ReHo value, mainly in frontal lobe and precentral and posteentral gyrus. The AS group also show abnormality in cingulate gyrus and parahippocampal gyrus. Conclusions Frontal lobe function abnormality is fundamental basis in schizophrenia patients with no violent behavior, while cingulate gyrus and parabippocampal gyrus play an important role in violence behavior in schizophrenics.