精神分裂症患者的胆红素特点及转归

Characteristics and outcomes of bilirubin in drug naive patients with schizophrenia

目的 探索精神分裂症患者的胆红素特点及用药后的转归情况.方法 选择新入院精神分裂症患者81例作为研究组,77名健康体检者作为对照组,收集对照组及研究组用药前后的总胆红素（T-BIL）、直接胆红素（D-BIL）、间接胆红素（I-BIL）、丙氨酸转氨酶（ALT）资料进行分析比较.结果 研究组用药前T-BIL、D-BIL、I-BIL、ALT水平与对照组比较,差异无统计学意义（P＞0.05）,I-BIL异常率低于对照,差异有统计学意义（χ^2=4.286,P＜0.05）.用药后T-BIL、D-BIL、I-BIL下降,ALT升高,差异有统计学意义（P＜0.05）,且胆红素水平与肝功能的相关性消失.结论 精神分裂症患者存在氧化防御系统缺陷,用药后出现胆酶分离现象,提示抗精神病药物可能在其转归上起到重要作用.

Objective To explore the characteristics ot bilirubin in drug naive patients with schizo- phrenia and its outcomes after antipsychotics treatment. Methods With 81 schizophrenia patients un treated at least three months before admitted to hospital as the case group, 77 healthy physical examination volunteers matched sex and age as control group, data of serum levels of total bilirubin （TB）, conju gated bilirubin （CB）, unconjugated hilirubin （UCB） and alanine aminotransferase （ALT） was collected and analyzed by chi square test and paired t test. Results The difference between levels of T--BIL, D-- BIL, I--BIL, ALT in case group and that in control group, was not statistically significant （P〈 0.05）. The abnormal rate of I--BIL was lower than that of the control, the difference was statistically signifi- cant （χ^2= 4. 286, P 〈0.05）. After antipsychotic treatment, T-- BIL, D-- BIL, I-- BIL decreased, and ALT increased, the difference was statistically significant （P 〈0.05）, and the correlation disappeared. Conclusions The results support that patients with schizophrenia have defects in oxidative defense system. The phenomenon of bilirubin separation ALT after treatment suggests that antipsychotic drugs may play an important role in its outcomes.