地西泮联合苯巴比妥对小儿惊厥患者的临床效果研究

Clinical effect of diazepam and phenobarbital in children with febrile convulsion

目的 探讨地西泮联合苯巴比妥治疗小儿惊厥患者的临床效果.方法 选取小儿惊厥患者70例,按随机数字表法分为对照组和试验组,每组35例,对照组患儿给予苯巴比妥药物治疗,试验组患儿给予地西泮联合苯巴比妥药物治疗.观察比较两组临床效果与并发症发生情况.结果 两组患儿均在1h内治愈.试验组患儿30 min内的治疗有效率为88.6％（31/35）,明显高于对照组的74.3％（26/35）,差异有统计学意义（P＜0.05）.试验组患儿复发率为2.9％（1/35）,明显低于对照组的14.3％（5/35）,差异有统计学意义（P＜0.05）.两组并发症发生情况比较差异无统计学意义（P＞0.05）.结论 对小儿惊厥患者使用地西泮联合苯巴比妥的药物治疗,可以迅速提高临床治疗效果,降低惊厥复发的几率,并且不良反应及并发症少,是临床治疗中的理想治疗方式.

Objective To study the clinical effect of diazepam and phenobarbital in children with febrile convulsion.Methods Seventy cases of febrile convulsion patients were divided into control group （phenobarbital treatment,35 cases） and experiment group （diazepam combined with phenobarbital,35 cases） by random digits table method,and compared the efficacy and complications.Results Two groups were cured within 1 h.The effective rate within 30 min in experiment group was significantly higher than that in control group [88.6% （31/35） vs.74.3% （26/35）] （P 〈 0.05）.The recurrent rate in experiment group was significantly lower than that in control group [2.9% （1/35） vs.14.3% （5/35）] （P 〈 0.05）.The complications had no statistically significant differences between two groups（P 〉 0.05）.Conclusions Diazepam combined with phenobarbital are very effective for children with febrile convulsion,can greatly improve clinical efficacy,decrease recurrent rate,and won＇t produce adverse reaction and complications,are the ideal treatment in the clinical treatment.