益丹护肾汤对慢性肾炎模型大鼠的药效学研究

Pharmacodynamics Study of Yidan Hushen decoction on chronic glomerulonephritis in rats

研究益丹护肾汤对慢性肾炎模型大鼠的治疗效果。方法:给Wistar大鼠腹腔注射同种大鼠肾皮质和弗氏完全佐剂液,复制大鼠主动型Heymann肾炎模型,并分为Heymann肾炎模型组、地塞米松组、益丹护肾汤高、中、低剂量组和空白对照组共6组。分别在给药处理后5d、10d、15d、20d定量测定其24h尿蛋白、尿素氮、肌酐、超氧化物歧化酶(SOD)、丙二醛(MDA)等。结果:益丹护肾汤组能降低尿蛋白、肌酐、尿素氮和MDA含量,与模型对照组比较,差异具统计学意义(P<0.05)。结论:益丹护肾汤对慢性肾炎大鼠有治疗作用。

Objective To study the effect of Yidan Hushen Decoction on chronic glomerulonephritis in the rats.Method Heymann nephritis model was induced by intraperitoneal injection of the same renal cortex and Freund＇s complete adjuvant in the rats.The rats were randomly divided into six groups：model group,Dexamethasone group,Yidan Hushen Decoction high dose group,middle dose group ,low dose group and control group.Measuring 24 hour urine protein,usea nitrogen ,creatinine,SOD MDA in 5d、10d、15d、20d after administration of treatment .Result Yidan Hushen Decoction group can reduce the content of urine protein,creatinine,usea nitrogen,and MDA （P〈0.05 ）.Conclusion Yidan Hushen Decoction has treatment effect on chronic glomerulonephritis.