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生长分化因子15在心血管疾病中的研究进展 被引量：2

Research progress in growth differentiation factor 15 and cardiovascular diseases
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摘要 生长分化因子15(GDF-15)是细胞因子超家族转化生长因子-β中的成员。在生理条件下GDF-15在心肌中呈弱表达,而在诸多病理条件下其表达水平增加。越来越多的证据表明,GDF-15水平升高是心血管疾病的一种很有价值的预后标志物。此外,GDF-15对心肌细胞具有内源性抗肥厚和拮抗心脏缺血/再灌注损伤的性质。GDF-15正在成为评估和管理心脏病患者的一种很有前途的生物学标志物,并对心肌细胞具有潜在的保护作用。 Growth-differentiation factor 15 （GDF-15） is a distant member of the transforming growth fac-tor-β cytokine superfamily. In myocardium, GDF-15 is weakly expressed under physiological conditions.However, its expression level is increased in response to pathological stress. Growing evidence indicatesthat the elevated level of GDF-15 is a promising prognostic biomarker in cardiovascular diseases. Moreover,GDF-15 exhibits the properties of endogenous anti-hypertrophy of cardiomyocytes and protecting the heartfrom ischemia and reperfusion insult.
作者 刘海涛 张海锋 尹涛 李飞 李伟杰 王海昌
机构地区 第四军医大学西京医院心血管内科 第四军医大学基础医学教学实验中心
出处 《心脏杂志》 CAS 2014年第3期361-365,共5页 Chinese Heart Journal
关键词 生长分化因子15 心血管疾病 标志物 growth-differentiation factor 15 biomarker cardiovascular disease protection
分类号 R543 [医药卫生—心血管疾病]
  • 相关文献

参考文献37

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二级参考文献18

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共引文献4

同被引文献14

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引证文献2

二级引证文献13

心脏杂志
2014年 第3期

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