PCT、hs-CRP和Nst分类计数联合检测在新生儿败血症诊断中的应用

Application of the PCT,hs-CRP and Nst counts for diagnosis in neonatal sepsis

目的评价降钙素原(PCT)、超敏C反应蛋白(hs-CRP)和中性杆状核粒细胞(Nst)分类计数联合检测在新生儿败血症诊断中的价值。方法比较35例败血症组与30例对照组血中PCT、hs-CRP和Nst比值的差异。结果新生儿败血症组PCT、hs-CRP和Nst比值水平分别为(23.51±10.02)ng/ml、(19.54±8.92)mg/L、(20±8.5)%,明显高于对照组,差异有统计学意义(P<0.05);治疗后明显下降,与治疗前比较差异有统计学意义(P<0.05)。PCT灵敏度、特异度、阳性预测值和阴性预测值比hs-CRP及Nst高,但联合检测PCT、hs-CRP和Nst的灵敏度比单独PCT高。结论 PCT、hs-CRP和Nst比值可作为新生儿败血症快速有效诊断的检测指标,联合检测可进一步提高检出率。

Objective Evaluation of procalcitonin （PCT）, hypersensitive c-reactive protein （hs-CRP） and neutral rod nucleus granulocyte （Nst） testings for diagnosis and treatment of neonatal sepsis. Method Blood PCT, hs-CRP and Nst ratios of 30 cases of sepsis group and 35 cases of control group were compared. Results The PCT, hs-CRP and Nst ratio levels of the neonatal sepsis group were significantly higher than those of control group （P〈0.05）. These ratios of acute period were significantly higher than those of recovery period （P〈0.05）. Conclusion PCT, hs-CRP and Nst ratios can he used as neonatal sepsis quick and efficient diagnostic indicators and joint detection of these markers can further improve the detection rate.