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极小胚胎样干细胞的研究现状和眼科临床意义 被引量：1

New trends and clinical significance of very small embryonic-like stem cells in Ophthalmology
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摘要 极小胚胎样干细胞(very small embryonic-like stem cells,VSELs)是美国路易斯维尔大学Kucia研究小组从小鼠骨髓和人脐带血中分离出一种具有类似胚胎干细胞生物特性的多潜能成体干细胞。与胚胎干细胞相似的外表——细胞形态及表面标志、以及相似的内在——多分化潜能决定了VSELs一出现就被细胞替代疗法视为最有潜力的种子细胞,本文就VSELs的研究历程及在眼科干细胞治疗视网膜退行性疾病中的临床意义作一综述。 Very small embryonic-like stem cells（ VSELs） is a rare population of pluripotent adult stem cells, whose biological nature is similar to that of embryonic stem cells, firstly identified in murine bone marrow （ BM） and human cord blood （ CB ） by Kucia and his group in University of Louisville. They have similar outlook to embryonic stem cells such as cell morphology and markers and similar inner pluripotent characteristics which make them be the most potential seed cells in the cell replacement therapy. In this review, we will focus on research advance about VSELs and clinical significance in the stem cell transplantation treatment of retinal degenerative diseases.
作者 肖庆 高玲 唐罗生 赵屹女 孙红晶
机构地区 浙江大学医学院附属第二医院滨江院区 杭州市滨江医院眼科 中南大学湘雅二医院眼科
出处 《国际眼科杂志》 CAS 2014年第5期842-845,共4页 International Eye Science
关键词 极小胚胎样干细胞 视网膜退行性疾病 干细胞移植/治疗 very small embryonic-like stem cells retinal degenerative diseases stem cell transplantation/treatment
分类号 R774.1 [医药卫生—眼科]
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共引文献10

同被引文献33

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国际眼科杂志
2014年 第5期

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