疏肝理浊法干预早期糖尿病微观辨证要素研究

Study on micro differentiation elements of shuganlizhuo method in the early diabetic patients

目的:从中医药理论探讨疏肝理浊法对改善湿热型早期糖尿病患者眼底微血管病变的疗效研究。方法:选取56例体质辨证为湿热型的早期糖尿病患者,其中治疗组28例,对照组28例。治疗组口服疏肝理浊方(舒和胶囊),对照组口服阿卡波糖片,均连续用3个疗程。观察两组治疗前后中医各项症候表现、视力、视野以及负荷后2h血糖(P2HBG)、糖化血红蛋白(HbA1c)。结果:治疗组能显著改善患者各项症候体征(P<0.01)、P2HBG和HbA1c,提高眼视力(P<0.05),降低视野平均缺损MD值(P<0.01)。结论:疏肝理浊法有改善湿热型早期糖尿病患者眼底微观病变的作用,可能与其通过改善全身症候有关。

AIM：To improve the efficacy pathological changes of retinal microvessel in the early damp - heat diabetic patients from TCM theory of shuganlizhuo. METHODS： Totally 56 patients with early damp-heat diabetic, 28 cases in treatment group and another 28 cases in control group. The treatment group treated with shuganlizhuo prescription （ Shuhe capsules） , the control group with Acarbose, all in a row with three courses. TCM syndrome manifestations, visual acuity, field of vision, as well as 2h postprandial blood glucose （ P2HBG ） and glycosylated hemoglobin （ HbA1c ） between the two groups before and after treatment were observed. RESULTS： The treatment group was able to＆amp;nbsp;significantly improve the TCM symptoms （ P〈 0. 01 ）, P2HBG, and HbA1c, improved visual acuity （P〈0. 05）, reduced visual field defects MD average values （ P 〈0.01）. CONCLUSION： The method of shuganlizhuo has improved micro lesions of early damp- heat diabetic retinal effects may be related to improve the systemic symptoms.