药物性肝损害56例分析

Analysis of Drug-induced Liver Damage about 56 Cases

目的通过对56例药物性肝损害住院患者的病因,临床特点、诊治情况分析,提高对本病的认识。方法回顾性分析56例在我院住院的药物性肝损害患者。结果引起药物性肝损害的重要药物为中药或中成药21例占37.5%,其次为抗生素10例占17.85%,临床类型为肝细胞型多见占60.72%,胆汁淤积型占12.5%,混合型占26.78%;主要临床表现有纳差、乏力、黄疸、恶心、呕吐等;肝功能受损以ALT、AST、GGT和ALP增高为主。结论多种药物均可引起肝损害,以中药和抗生素为主,及时停用肝损害药物是治疗的关键,大多数患者经积极治疗预后良好。

Objective 56 cases of hospitalized patients with drug-induced liver damage causes, clinical characteristics, diagnosis and treatment, improve the understanding of the disease. Methods Retrospective analysis of 56 cases hospitalized in our hospital patients with drug-induced liver damage. Results Drug-induced liver damage caused by the results of the important drug for traditional Chinese medicine or proprietary Chinese medicine 21 cases（37.5%）, 10 cases （17.85%）, followed by antibiotic clinical types for liver cell see more accounted for 60.72%, cholestasis type 12.5%, mixed type（26.78%）; The main clinical manifestations are NaCha, lack of power, jaundice, nausea, vomiting, etc; Liver damage is given priority to with ALT, AST, GGT and ALP increased. Conclusion Multiple medications can cause liver damage, give priority to with Chinese medicine and antibiotics, stop using drugs liver damage is the key to the treatment in time, most of the patients after active treatment prognosis is good.