孕妇血小板抗体与新生儿血小板减少的相关性研究

Study on the Correlation of Maternal Platelet Antibodies and Neonatal Thrombocytopenia

目的探讨孕妇血小板变化对新生儿血小板减少的影响,从而为临床治疗和护理提供科学的理论依据。方法随机选取2012年6月至2013年10月以来在我院待产且合并血小板减少的孕妇81例作为观察组,选取同期入院的79例血小板正常的孕妇作为对照组,采用ELISA和流式细胞仪检测孕妇血小板表面特异、非特异性抗体,分析抗体量与新生儿血小板计数的相关性。结果患血小板减少症的孕妇所生的新生儿血小板减少率为32.09%,明显高于血小板正常孕妇所生新生儿的血小板减少率(6.33%)P<0.05,差异有统计学意义。结论孕妇患有血小板减少性相关疾病会导致新生儿血小板减少,孕妇血小板抗体阳性与新生儿血小板减少具有相关性,临床医师和护士需要根据妊娠不同时期孕妇血小板抗体的变化,采取科学合理的治疗与护理措施,避免造成新生儿血小板减少。

Objective To investigate the effects of maternal neonatal thrombocytopenia, platelet changes, thus providing a scientific basis for clinical treatment and care. Methods Randomly selected since June 2012 in October 2013 in our hospital to be produced and thrombocytopenia in 81 cases of pregnant women as the observation group, select the same period 79 cases of hospitalized pregnant women of normal platelets as a control group, using ELISA and flow cytometry pregnant detected specific platelet surface, non-specific antibody, the amount of antibody analysis of platelet count and neonatal correlation. Results The risk of thrombocytopenia thrombocytopenia in neonates born to pregnant women was 32.09%, significantly higher than normal platelet thrombocytopenia in neonates born to pregnant women, the rate of（6.33%）P〈0.05, the difference was statistically significant. Conclusion Pregnant women with thrombocytopenia-related diseases can cause neonatal thrombocytopenia, platelet antibody-positive pregnant women and neonatal thrombocytopenia relevant, clinicians and nurses need to change platelet antibodies in pregnant women according to different periods of pregnancy, take a scientific and rational treatment and care measures to avoid causing neonatal thrombocytopenia.