生长抑素联合铝碳酸镁对非甾体抗炎药致老年急性出血糜烂性胃炎患者的疗效分析

The efficacy of somatostatin combined with hydrotalcid for elderly patients with acute hemorrhagic erosive gastritis induced by non-steroidal anti-inflammatory drugs

目的探讨生长抑素联合铝碳酸镁对非甾体抗炎药(NSAIDs)致老年急性出血糜烂性胃炎患者的疗效。方法将136例NSAIDs致老年急性出血糜烂性胃炎患者随机分为观察组和对照组,对照组给予铝碳酸镁片治疗,观察组在对照组的基础上加用生长抑素,比较两组黑便、大便潜血消失时间、住院时间及治疗有效率。结果观察组黑便、大便潜血消失时间、住院时间均低于对照组,与对照组比较差异有统计学意义(P<0.05)。观察组治疗后总有效率高于对照组,与对照组比较差异有统计学意义(P<0.05)。结论生长抑素联合铝碳酸镁对NSAIDs致老年急性出血糜烂性胃炎患者的治疗效果较好,可缩短患者住院的时间,改善患者临床症状,有效抑制出血,具有较好的应用价值。

Objective To investigate the efficacy of somatostatin combined with hydrotalcid for elderly patients with non-steroidal anti-inflammatory drugs （NSAIDs） induced acute hemorrhagic erosive gastritis.Methods One hundred and thirty-six cases of elderly patients with acute hemorrhagic erosive gastritis induced by NSAIDs were randomly divided into the observation group and the control group,the control group were given hydrotalcid tablets,the observation group were given somatostatin combined with hydrotalcid.The disappeared time of black fecal,the disappeared time of fecal occult blood,hospitalization time and treatment efficiency were compared between two groups.Results The disappeared time of black fecal,the disappeared time of fecal occult blood and hospitalization time of the observation group were less than those of the control group （P ＜ 0.05）.The total effective rate of the observation group was higher than that of the control group （P ＜ 0.05）.Conclusion Somatostatin combined with hydrotalcid for elderly patients with acute hemorrhagic erosive gastritis induced by NSAIDs is effective,which could reduce the hospitalization time,improve clinical symptoms,inhibit bleeding,and has good application value.