S-腺苷蛋氨酸对梗阻性黄疸患者肝蛋白质合成及肝功能的影响

The effect of S-adenosyl-L-methionyne on liver protein and liver function of patients with obstructive jaundice

目的探讨S-腺苷蛋氨酸(SAMe)对梗阻性黄疸患者肝蛋白质合成及肝功能的影响。方法选取梗阻性黄疸患者60例,依据单双号分为观察组和对照组,各30例,两组患者均给予常规保肝治疗,在此基础上观察组加用SAMe 1 g静脉滴注,两组均治疗7 d,比较治疗前后前清蛋白(PA)、清蛋白(ALB)、转铁蛋白(TF)、天冬氨酸氨基转移酶(AST)、谷氨酸氨基转移酶(ALT)、总胆红素(TBIL)、直接胆红素(DBIL)、谷酰转肽酶(GGT)、碱性磷酸酶(ALP)变化。结果观察组患者在治疗后PA较治疗前明显升高(P<0.05),治疗后浓度高于对照组(P<0.05),对照组治疗后TF较治疗前有所下降(P<0.05),治疗后浓度低于观察组(P<0.05),两组在治疗前后ALB均无明显变化(P>0.05);两组治疗后AST、ALT、TBIL、DBIL、GGT、ALP较治疗前均有所下降(P<0.05),观察组以上肝功能指标下降幅度明显较对照组高(P<0.05)。结论 SAMe用于治疗梗阻性黄疸能促进患者肝蛋白质合成及改善肝功能。

Objective To investigate the effect of S-adenosyl-L-methionyne on liver protein and liver function of patients with obstructive jaundice.Methods Sixty patients with obstructive jaundice were divided into observation group and control group.All the patients were treated with traditional treatment of protecting liver,while the patients in observation group were given 1 g SAMe static drop,for 7 consecutive days in both two groups.Then the levels of prealbumin （PA）,albumin （ALB）,transferrin （TF）,aspartate aminotransferase （AST）,glutamic acid aminotransferase （ALT）,total bilirubin （TBIL）,bilirubin direct （DBIL）,Gamma-Glutamyl Transpeptidase （GGT）,alkaline phosphatase （ALP） before and after treatment were compared between two groups.Results Compared with before treatment,the level of PA in observation group was increased significantly after treatment （P ＜ 0.05）,the level of PA in observation group was higher than that in control group after treatment （P ＜ 0.05）.The level of TF was decreased in control group after treatment compared with before treatment （P ＜ 0.05）,the level of TF in control group was lower than that in observation group after treatment （P ＜ 0.05）.The change of ALB before and after treatment was not significant in two groups （P ＞ 0.05）.Compared with before treatment,the levels of AST,ALT,TBIL,DBIL,GGT,ALP after treatment were significantly decreased in observation group and control group （P ＜ 0.05）,decreased ranges of above liver function indicators in observation group were more obvious than those in control group （P ＜ 0.05）.Conclusion SAMe can promote protein synthesis in the liver and improve liver function of patients with obstructive jaundice.