长期治疗后运动强度对非酒精性脂肪性肝病的影响

Effects of exercise intensity on nonalcoholic fatty liver disease after long-term treatment

目的探讨经长期治疗后运动强度对非酒精性脂肪性肝病(NAFLD)的影响。方法收集上海交通大学医学院附属仁济医院脂肪性肝病诊治研究中心诊断为NAFLD的随访患者,排除没有控制饮食的患者、没有进行有氧运动治疗的患者、1个月内接受药物治疗的患者。根据运动强度,将患者分为基础强度组、低强度组、中等强度组,所有患者均接受饮食治疗,回顾性分析不同运动强度对NAFLD的影响。结果与运动干预前比较,基础强度可使体质量、腰围、WHR、FAT%、BMI有部分下降,但差异无统计学意义(P>0.05);低强度可使体质量、FAT%下降,差异均有统计学意义(P均<0.05),B超检查示脂肪肝程度减轻,但差异无统计学意义(P>0.05);中等强度可使体质量、WHR、BMI下降,B超检查示脂肪肝程度减轻,差异均有统计学意义(P均<0.05)。结论在NAFLD的长期治疗中,增加运动强度至中等强度可以维持较好的效果。

Objective To investigate the effects of exercise intervention of different intensities in nonalcoholic fatty liver disease （NAFLD） patients after long-term treatment.Methods Patients diagnosed with NAFLD in our research center were recruited during follow-up.Patients treated without diet modification or aerobic exercise interventions or patients receiving drug treatment during the previous month were excluded.The patients were divided into the following groups according to exercise intensity：basic,low and moderate.These patients were treated by diet modification.The effects of exercise intervention of different intensities on NAFLD patients were analyzed retrospectively.Results Compared with before the exercise intervention,body weight,waist circumference,waist-to-hip ration （WHR）,percentage body （FAT％） and body mass index （BMI） were decreased （without statistical significance） in the basic intensity group（P ＞0.05）.Body weight and FAT％ were decreased in the low intensity group （P ＜0.05） and B ultrasonic examination showed alleviation of liver damage,difference had no statistical significance （P ＞ 0.05）.In the moderate intensity group,body weight,WHR and BMI were decreased significantly and B ultrasonic examination showed significant alleviation of the liver damage （P ＜ 0.05）.Conclusion In the long-term treatment of NAFLD,exercise of moderate intensity is associated with alleviation of liver damage as well as benefits to the patients in terms of a reduction in body weight,WHR and BMI.